As of 2007, 31 genera and 78 species are in this family. Wertheimeria is considered to be the sister taxon to all other doradids. This family is monophyletic and contains the subfamilies Doradinae, Astrodoradinae and Wertheimerinae.

The Astrodoradinae contain the genera Amblydoras, Anadoras, Astrodoras, Hypodoras, Merodoras, Physopyxis, and Scorpiodoras.

These fish are native to South America, primarily the Amazon basin and the Guianas.
Gallagher's Thorny Catfish
Threespot mouse catfish
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